Pathway
Antigen presentation via MHC-II
Peptide-MHC-II presentation to CD4 T cells.
Also called: MHC-II presentation, HLA class II presentation, antigen presentation MHC class II
In short
- 1What it is: a pathway in foundations.
- 2How it connects: acts on 2 and is affected by 1 concepts — mostly 2 cell, 1 receptor.
- 3Where it sits: recognition, response on the 15-step immune chain.
What it does
APC-restricted; CD4+ T cell activation; peptide 13-25aa loaded in endosome; HLA polymorphism determines which self-peptides are presented → autoimmune disease susceptibility (HLA-DRB1*15:01 → MS 6×; HLA-DRB1 SE → seropositive RA; HLA-DQ2/DQ8 → T1DM)
Its connections at a glance
Each dot is a concept directly linked to Antigen presentation via MHC-II. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID P005 · concept status: established. Select any connection above to inspect evidence for that specific link.