Pathway

cGAS-STING pathway

Cyclic GMP-AMP synthase → STING: cGAS binds cytoplasmic dsDNA (always abnormal: viral, tumour genomic instability, mitochondrial damage, NET DNA in SLE) → produces cGAMP (cyclic dinucleotide) → activates STING (ER-resident adaptor) → TBK1 → IRF3 → IFN-β + NF-κB.

Also called: cGAS-STING, innate DNA sensing, stimulator of interferon genes

Sparsely connected — only 1 link recorded so far.

Ask about cGAS-STING pathway See in graph Sources

In short

1What it is: a pathway in signalling and mechanisms.
2How it connects: acts on 1 and is affected by 0 concepts — mostly 1 molecule.
3Where it sits: trigger, signalling, target on the 15-step immune chain.

What it does

2023 Lasker Award.

Its connections at a glance

Each dot is a concept directly linked to cGAS-STING pathway. Colours show the kind of concept.

Sources & evidenceloading…

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Graph ID P011 · concept status: established. Select any connection above to inspect evidence for that specific link.