Molecule
Type I interferon
IFN-α (produced mainly by pDCs, 13 subtypes) and IFN-β (produced by most nucleated cells on viral dsRNA sensing via RIG-I/MDA5/cGAS-STING).
Also called: IFN-α, IFN-β, interferon alpha, interferon beta, type 1 interferon
In short
- 1What it is: a molecule in molecules and receptors.
- 2How it connects: acts on 2 and is affected by 1 concepts — mostly 1 molecule, 1 receptor, 1 pathway.
- 3Where it sits: signalling, failure, target on the 15-step immune chain.
What it does
SLE: NET-released DNA → pDC TLR7/9 → IFN-α → BAFF → autoreactive B cell rescue.
Its connections at a glance
Each dot is a concept directly linked to Type I interferon. Colours show the kind of concept.
Learn next
Sources & evidenceloading…
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Graph ID M018 · concept status: established. Select any connection above to inspect evidence for that specific link.