Therapy
Etanercept
Soluble TNF receptor fusion protein.
Also called: etanercept, Enbrel, ETN
In short
- 1What it is: a therapy in therapies and applications.
- 2How it connects: acts on 3 and is affected by 0 concepts — mostly 1 molecule, 1 disease, 1 therapy.
- 3Where it sits: therapy on the 15-step immune chain.
What it does
TNFR2-Fc decoy protein; binds soluble TNF only (cannot bind membrane-bound TNF → no reverse signalling → does not work in fistulising Crohn's disease); lower TB reactivation risk vs other anti-TNFs (granuloma membrane TNF less affected); does not work in UC or CD (hence no IBD approval); not a monoclonal antibody (no ADCC, no CDC)
Its connections at a glance
Each dot is a concept directly linked to Etanercept. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID I007 · concept status: established. Select any connection above to inspect evidence for that specific link.