Receptor
FcεRI
High-affinity IgE receptor (Kd ~10^-10 M) constitutively expressed on mast cells and basophils.
Also called: high-affinity IgE receptor, IgE receptor
In short
- 1What it is: a receptor in molecules and receptors.
- 2How it connects: acts on 1 and is affected by 3 concepts — mostly 3 cell, 1 molecule.
- 3Where it sits: trigger, recognition, target on the 15-step immune chain.
What it does
Omalizumab (anti-IgE → free IgE falls → FcεRI receptor downregulates because receptor requires ligand for surface expression) → reduces mast cell/basophil arming; OUtMATCH: 67% of peanut-allergic children tolerated 600mg peanut protein (FDA 2024)
Its connections at a glance
Each dot is a concept directly linked to FcεRI. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID R014 · concept status: established. Select any connection above to inspect evidence for that specific link.