Pathway
Germinal-centre reaction
B-cell selection, class switching and affinity maturation.
Also called: GC reaction, germinal centre reaction, affinity maturation
In short
- 1What it is: a pathway in signalling and mechanisms.
- 2How it connects: acts on 3 and is affected by 9 concepts — mostly 3 cell, 2 molecule, 1 receptor.
- 3Where it sits: response on the 15-step immune chain.
What it does
AID-driven SHM (affinity maturation) + class switching; Darwinian selection by FDC + Tfh signals; produces high-affinity IgG plasma cells + memory B cells; also generates oncogenic translocations (BCL2 t(14;18)→follicular lymphoma; MYC t(8;14)→Burkitt lymphoma)
Its connections at a glance
Each dot is a concept directly linked to Germinal-centre reaction. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID P008 · concept status: established. Select any connection above to inspect evidence for that specific link.