Cell
Macrophage
Tissue phagocyte with context-dependent inflammatory, antimicrobial and repair states.
Also called: M1 macrophage, M2 macrophage, tissue macrophage, TAM, alveolar macrophage, Kupffer cell, microglia, synovial macrophage
In short
- 1What it is: a cell in cells and organs.
- 2How it connects: acts on 7 and is affected by 5 concepts — mostly 1 cell, 5 molecule, 1 pathway.
- 3Where it sits: recognition, signalling, response, failure, target on the 15-step immune chain.
What it does
TNF/IL-6/IL-1β production drives RA synovitis; macrophage IL-6 drives COVID-19 ARDS mortality (RECOVERY: dexamethasone benefit only in oxygen-requiring patients); M2/TAM drives cold tumour immune exclusion; FOLR2+ macrophage = universal cold tumour gatekeeper (Nature 2024 AI discovery).
Its connections at a glance
Each dot is a concept directly linked to Macrophage. Colours show the kind of concept.
Sources & evidenceloading…
Loading reviewed sources…
Graph ID C003 · concept status: established. Select any connection above to inspect evidence for that specific link.