Tissue

Tumour microenvironment

Local ecosystem of malignant, immune and stromal cells.

Also called: TME, tumour microenvironment, tumour milieu

Ask about Tumour microenvironment See in graph Sources

In short

1What it is: a tissue in cells and organs.
2How it connects: acts on 1 and is affected by 2 concepts — mostly 1 cell, 1 disease, 1 discovery.
3Where it sits: failure, target on the 15-step immune chain.

What it does

Immunosuppressive milieu: Tregs (CCL2/5/22 recruited), MDSCs (arginase-1, iNOS), M2 TAMs (IL-10/TGF-β/VEGF), adenosine (CD39+CD73), IDO (tryptophan depletion → kynurenine → Treg induction); cold tumour = absent TIL (WNT/β-catenin → no DC recruitment); STING agonists (diABZI) 'heat' cold tumours; FOLR2+ macrophage = universal TME gatekeeper (AI discovery Nature 2024)

Its connections at a glance

Each dot is a concept directly linked to Tumour microenvironment. Colours show the kind of concept.

Learn next

Comes beforeMyeloid-derived suppressor cellCell Comes beforeFOLR2+ tissue-resident macrophagesDiscovery Leads toCancer immune escapeDisease

Sources & evidenceloading…

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Graph ID T007 · concept status: established. Select any connection above to inspect evidence for that specific link.