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Biomarker

C-reactive protein (CRP)

Acute-phase protein used as a systemic inflammation marker.

Also called: CRP, C-reactive protein

Ask about C-reactive protein (CRP) See in graph Sources

In short

  1. 1What it is: a biomarker in research methods.
  2. 2How it connects: acts on 1 and is affected by 3 concepts — mostly 1 pathway, 1 tissue, 1 disease.
  3. 3Where it sits: biomarker on the 15-step immune chain.

What it does

Acute phase reactant (IL-6-driven hepatic production); rises within 6-8h of inflammatory stimulus; falls rapidly with resolution; clinical TRAP: tocilizumab/sarilumab suppress CRP production (block IL-6R) → CRP cannot be used to monitor infection or inflammation in patients on IL-6R antagonists; hsCRP (high-sensitivity) used in CANTOS (>2mg/L → enrolled; fell with canakinumab confirming anti-IL-1β mechanism)

Its connections at a glance

Each dot is a concept directly linked to C-reactive protein (CRP). Colours show the kind of concept.

Rheumatoid arthritisTocilizumabAcute-phase responseBloodC-reactive protein (CRP)

Learn next

Comes beforeRheumatoid arthritisDiseaseComes beforeTocilizumabTherapyComes beforeAcute-phase responsePathway
Sources & evidenceloading…

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Graph ID B001 · concept status: established. Select any connection above to inspect evidence for that specific link.