Molecule
IL-33
IL-1 family alarmin; released by stressed/necrotic epithelial cells; binds ST2 receptor on ILC2, mast cells, Th2 cells, Tregs → NF-κB + MAPK → type-2 cytokine cascade.
Also called: interleukin-33
In short
- 1What it is: a molecule in molecules and receptors.
- 2How it connects: acts on 2 and is affected by 0 concepts — mostly 1 cell, 1 pathway.
- 3Where it sits: trigger, signalling on the 15-step immune chain.
What it does
Itepekimab (anti-IL-33, REGN3500): Phase 3 asthma (LIBERTY ASTHMA QUEST).
Its connections at a glance
Each dot is a concept directly linked to IL-33. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID M021 · concept status: evidence-supported. Select any connection above to inspect evidence for that specific link.