Molecule
APRIL
A proliferation-inducing ligand: binds TACI and BCMA on plasma cells → plasma cell survival in bone marrow niche; shares TACI with BAFF.
Also called: TNFSF13, a proliferation-inducing ligand
Sparsely connected — only 1 link recorded so far.
In short
- 1What it is: a molecule in molecules and receptors.
- 2How it connects: acts on 1 and is affected by 0 concepts — mostly 1 receptor.
- 3Where it sits: failure, target on the 15-step immune chain.
What it does
Key distinction from BAFF: APRIL maintains long-lived plasma cell survival in bone marrow → explains why belimumab (anti-BAFF only) spares plasma cells; atacicept (BAFF+APRIL trap) Phase 3 NEPTUNE (SLE) data expected 2025-2026
Its connections at a glance
Each dot is a concept directly linked to APRIL. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID M017 · concept status: emerging. Select any connection above to inspect evidence for that specific link.