Molecule
TNF
Pro-inflammatory cytokine with major roles in tissue inflammation and granuloma biology.
Also called: TNF-α, tumour necrosis factor alpha, tumour necrosis factor
In short
- 1What it is: a molecule in molecules and receptors.
- 2How it connects: acts on 6 and is affected by 6 concepts — mostly 1 cell, 2 receptor, 3 tissue.
- 3Where it sits: signalling, consequence, target on the 15-step immune chain.
What it does
Granuloma maintenance (anti-TNF → TB/fungal reactivation, mandatory LTBI screening before anti-TNF); TNFR2 cardioprotective on cardiomyocytes (anti-TNF absoluteLY contraindicated in CHF NYHA III-IV); membrane TNF → reverse signalling → macrophage/T cell apoptosis (infliximab/adalimumab fistula healing in CD; etanercept cannot bind membrane TNF → no reverse signalling → no fistula healing)
Its connections at a glance
Each dot is a concept directly linked to TNF. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID M001 · concept status: established. Select any connection above to inspect evidence for that specific link.