Molecule
IL-2
T cell autocrine growth factor: produced by activated CD4+ T cells; IL-2Rα (CD25, high-affinity chain, highest on Tregs) + IL-2Rβ (CD122) + IL-2Rγ (γc); JAK1/JAK3 → STAT5.
Also called: interleukin-2, IL2, T cell growth factor
Sparsely connected — only 1 link recorded so far.
In short
- 1What it is: a molecule in molecules and receptors.
- 2How it connects: acts on 1 and is affected by 0 concepts — mostly 1 cell.
- 3Where it sits: signalling, response, target on the 15-step immune chain.
What it does
LOW-dose IL-2 (1-3M IU SC, 5-day cycles): preferentially expands Tregs (CD25 high) → Phase 2 SLE (SLEDAI 8.1→4.7, Tregs 4-fold expansion); Phase 2 cGVHD, T1DM.
Its connections at a glance
Each dot is a concept directly linked to IL-2. Colours show the kind of concept.
Learn next
Sources & evidenceloading…
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Graph ID M020 · concept status: established. Select any connection above to inspect evidence for that specific link.