Cell
Mast cell
Tissue-resident mediator-releasing cell important in allergy and host defence.
Also called: tissue mast cell
In short
- 1What it is: a cell in cells and organs.
- 2How it connects: acts on 4 and is affected by 1 concepts — mostly 2 molecule, 2 receptor, 1 biomarker.
- 3Where it sits: response, failure, target on the 15-step immune chain.
What it does
FcεRI constitutively loaded with IgE → allergen crosslinks 2+ FcεRI → seconds: histamine, tryptase; minutes: PGD2, LTC4/D4/E4 (1000× more potent bronchoconstrictors than histamine); omalizumab (anti-IgE → FcεRI downregulation); avapritinib (KIT D816V → systemic mastocytosis ORR 75% FDA 2023)
Its connections at a glance
Each dot is a concept directly linked to Mast cell. Colours show the kind of concept.
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Sources & evidenceloading…
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Graph ID C007 · concept status: established. Select any connection above to inspect evidence for that specific link.