Receptor
IL-6R
Receptor component mediating IL-6 signalling.
Also called: IL-6 receptor, IL-6Rα, CD126, gp80
In short
- 1What it is: a receptor in molecules and receptors.
- 2How it connects: acts on 1 and is affected by 1 concepts — mostly 1 pathway, 1 therapy.
- 3Where it sits: signalling, target on the 15-step immune chain.
What it does
IL-6Rα (soluble + membrane) + gp130 (ubiquitous signal transducer) → JAK1/TYK2 → STAT3; tocilizumab (anti-IL-6Rα, binds soluble+membrane) vs sarilumab (anti-IL-6Rα different epitope) vs siltuximab (anti-IL-6 itself, not receptor)
Its connections at a glance
Each dot is a concept directly linked to IL-6R. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID R007 · concept status: established. Select any connection above to inspect evidence for that specific link.