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Pathway

T-cell receptor signalling

Signal integration downstream of TCR engagement.

Also called: TCR signalling, T cell receptor signalling, TCR/CD3 signalling

Ask about T-cell receptor signalling See in graph Sources

In short

  1. 1What it is: a pathway in signalling and mechanisms.
  2. 2How it connects: acts on 2 and is affected by 3 concepts — mostly 2 cell, 2 receptor, 1 therapy.
  3. 3Where it sits: recognition, signalling on the 15-step immune chain.

What it does

TCR+pMHC → ZAP-70 → LAT → PLCγ → Ca2+/PKCθ → NFAT/NF-κB/AP-1 → IL-2/CD25/CD69; PD-1→SHP-2 dephosphorylates ZAP-70 → T cell inactivation (anti-PD-1 restores ZAP-70 phosphorylation)

Its connections at a glance

Each dot is a concept directly linked to T-cell receptor signalling. Colours show the kind of concept.

TCRCD3Calcineurin inhibitorNaive CD4 T cellCD8 cytotoxic T lymph…T-cell receptor signalling

Learn next

Comes beforeTCRReceptorComes beforeCD3ReceptorComes beforeCalcineurin inhibitorTherapyLeads toNaive CD4 T cellCellLeads toCD8 cytotoxic T lymphocyteCell
Sources & evidenceloading…

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Graph ID P007 · concept status: established. Select any connection above to inspect evidence for that specific link.