Disease
Lupus nephritis
Class III/IV LN (proliferative): immune complex (anti-dsDNA IgG + complement) deposition in glomeruli → podocyte injury → proteinuria → CKD.
Also called: LN, lupus nephritis, Class III LN, Class IV LN, Class V LN
In short
- 1What it is: a disease in diseases and immunopathology.
- 2How it connects: acts on 0 and is affected by 3 concepts — mostly 1 disease, 1 therapy, 1 biomarker.
- 3Where it sits: failure, disease on the 15-step immune chain.
What it does
Treatment evolution: MMF+voclosporin (CNI, AURORA: 41% CRR vs 23% MMF alone); obinutuzumab+MMF (NOBILITY: 50% vs 30% CRR at 2yr, FDA 2025).
Its connections at a glance
Each dot is a concept directly linked to Lupus nephritis. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID D015 · concept status: established. Select any connection above to inspect evidence for that specific link.