Molecule
BAFF
B cell activating factor: produced by monocytes, DCs, neutrophils; IFN-α directly upregulates BAFF transcription in monocytes (connecting pDC IFN-α → B cell rescue in SLE).
Also called: BLyS, B lymphocyte stimulator, TNFSF13B
In short
- 1What it is: a molecule in molecules and receptors.
- 2How it connects: acts on 2 and is affected by 2 concepts — mostly 1 cell, 1 molecule, 1 receptor.
- 3Where it sits: signalling, failure, target on the 15-step immune chain.
What it does
Belimumab (anti-BAFF/BLyS): first biologic approved for SLE in 50 years (BLISS-52/76 2011, 48% annual flare rate reduction); best in: IFN-high + elevated anti-dsDNA + active non-renal manifestations; does NOT reach plasma cells (CD20-negative); atacicept (TACI-Ig) traps BAFF+APRIL → depletes B cells AND plasma cells
Its connections at a glance
Each dot is a concept directly linked to BAFF. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID M016 · concept status: established. Select any connection above to inspect evidence for that specific link.