Pathway
Type-I interferon signalling
IFN-I pathway leading to interferon-stimulated gene expression.
Also called: type I interferon signalling, IFN-I pathway, interferon alpha/beta signalling
In short
- 1What it is: a pathway in signalling and mechanisms.
- 2How it connects: acts on 2 and is affected by 8 concepts — mostly 2 cell, 1 molecule, 3 receptor.
- 3Where it sits: signalling, failure, target on the 15-step immune chain.
What it does
cGAS-STING→TBK1→IRF3→IFN-β; TLR7/9→IRF7→IFN-α (pDC dominant); IFNAR1/2→JAK1/TYK2→STAT1/2+IRF9→ISGF3→ISGs (IFIT1, MX1, OAS1); SLE: 75% of patients IFN-signature-high → anifrolumab (anti-IFNAR1) FDA 2021; ISG15+ macrophage exclusive to Class III/IV LN (AI discovery → explains anifrolumab mechanism in proliferative LN)
Its connections at a glance
Each dot is a concept directly linked to Type-I interferon signalling. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID P004 · concept status: established. Select any connection above to inspect evidence for that specific link.