Molecule
TGF-β
Context-dependent regulatory cytokine involved in Treg biology and tissue remodelling.
Also called: TGF-β, transforming growth factor beta, TGF-β
Sparsely connected — only 1 link recorded so far.
In short
- 1What it is: a molecule in molecules and receptors.
- 2How it connects: acts on 0 and is affected by 1 concepts — mostly 1 cell.
- 3Where it sits: signalling, response on the 15-step immune chain.
What it does
Treg induction (with IL-2 → Foxp3 stabilisation); Th17 generation (with IL-6); fibrosis (cGVHD FAP+ fibroblast activation; IPF); SMAD2/3 pathway; TNIK (Traf2-NCK Interacting Kinase) identified by PandaOmics AI as IPF driver → rentosertib (INS018_055) Phase 2a positive (Nature Medicine 2025: +98.4mL FVC vs -62.3mL placebo)
Its connections at a glance
Each dot is a concept directly linked to TGF-β. Colours show the kind of concept.
Learn next
Sources & evidenceloading…
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Graph ID M012 · concept status: established. Select any connection above to inspect evidence for that specific link.