Layer 04 · Knowledge graph
The causal map
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| Subject | Relation | Object | Status | Details |
|---|---|---|---|---|
| Macrophage | produces | TNF | Unreviewed | |
| Macrophage | produces | IL-1β | Unreviewed | |
| Macrophage | produces | IL-6 | Unreviewed | |
| TNF | binds | TNFR1 | Unreviewed | |
| TNF | binds | TNFR2 | Unreviewed | |
| TLR4 | activates | NF-κB signalling | Unreviewed | |
| TLR3 | activates | Type-I interferon signalling | Unreviewed | |
| TLR7 | activates | Type-I interferon signalling | Unreviewed | |
| NLRP3 | activates | NLRP3 inflammasome | Unreviewed | |
| NLRP3 inflammasome | matures | IL-1β | Unreviewed | |
| IL-1β | signals through | NF-κB signalling | Unreviewed | |
| IL-6 | signals through | JAK-STAT signalling | Unreviewed | |
| IL-12 | signals through | IL-12 receptor | Unreviewed | |
| IL-23 | signals through | IL-23R | Unreviewed | |
| IL-17A | signals through | IL-17RA | Unreviewed | |
| IFN-γ | activates | Macrophage | Unreviewed | |
| IL-12 | promotes | Th1 cell | Unreviewed | |
| IL-4 | promotes | Th2 cell | Unreviewed | |
| IL-5 | supports | Eosinophil | Unreviewed | |
| IL-13 | reinforces | Th2 cell | Unreviewed | |
| Conventional dendritic cell | presents antigen via | Antigen presentation via MHC-II | Unreviewed | |
| Conventional dendritic cell | presents antigen via | Antigen presentation via MHC-I | Unreviewed | |
| Antigen presentation via MHC-II | activates | Naive CD4 T cell | Unreviewed | |
| Antigen presentation via MHC-I | activates | CD8 cytotoxic T lymphocyte | Unreviewed | |
| Naive CD4 T cell | differentiates into | Th1 cell | Unreviewed | |
| Naive CD4 T cell | differentiates into | Th2 cell | Unreviewed | |
| Naive CD4 T cell | differentiates into | Th17 cell | Unreviewed | |
| Naive CD4 T cell | differentiates into | Treg cell | Unreviewed | |
| Th1 cell | produces | IFN-γ | Unreviewed | |
| Th2 cell | produces | IL-4 | Unreviewed | |
| Th2 cell | produces | IL-5 | Unreviewed | |
| Th2 cell | produces | IL-13 | Unreviewed | |
| Th17 cell | produces | IL-17A | Unreviewed | |
| Treg cell | produces | IL-10 | Unreviewed | |
| Treg cell | produces | TGF-β | Unreviewed | |
| Tfh cell | supports | B cell | Unreviewed | |
| B cell | differentiates into | Plasma cell | Unreviewed | |
| B cell | differentiates into | Memory B cell | Unreviewed | |
| Follicular dendritic cell | displays native antigen to | B cell | Unreviewed | |
| Germinal-centre reaction | supports | Memory B cell | Unreviewed | |
| CXCL8 / IL-8 | recruits | Neutrophil | Unreviewed | |
| Neutrophil | phagocytoses | Candida albicans | Unreviewed | |
| Th17 cell | supports recruitment of | Neutrophil | Unreviewed | |
| Plasmacytoid dendritic cell | produces | Type-I interferon signalling | Unreviewed | |
| Type-I interferon signalling | induces | Natural killer cell | Unreviewed | |
| CD8 cytotoxic T lymphocyte | kills | Influenza A virus | Unreviewed | |
| Mast cell | degranulates via IgE primed by | IL-4 | Unreviewed | |
| ILC2 | produces | IL-13 | Unreviewed | |
| Eosinophil | responds to | IL-5 | Unreviewed | |
| TNF | contributes to | Rheumatoid arthritis | Unreviewed |